Keep the lines of communication open with your team. Most online businesses have a lot of lookers. Even if your affiliates are unresponsive, don't give up. Keep messaging them. You never know when they will become active.
Try finding out what country they come from or which language they prefer. Use Google Translate to their native tongue. Perhaps their inactivity is due to a language barrier. If your opportunity allows you to transfer affiliates, try to find one from their home country and transfer them. As with any business, you have to be persistent and always be prompt with any questions or messages. Sometimes just a quick note of encouragement is enough to help your downline push on.
I recommend you post a message at least once a week to pass along your ideas, motivating quotes, goals, and other items related to your business.